Now accepting Telehealth appointments. Schedule a virtual visit.

Myelin oligodendrocyte glycoprotein (MOG)-associated disease (MOGAD)

Myelin oligodendrocyte glycoprotein (MOG)-associated disease (MOGAD) is an antibody-mediated inflammatory demyelinating disorder of the central nervous system (CNS) with various phenotypes starting from optic neuritis, via transverse myelitis to acute demyelinating encephalomyelitis (ADEM) and cortical encephalitis. The clinical picture of this condition is similar to the presentation of neuromyelitis optica spectrum disorder (NMOSD), most experts consider MOGAD to be a distinct entity with different immune system pathology. MOG is a molecule detected on the outer membrane of myelin sheaths and expressed primarily within the brain, spinal cord and optic nerve.

MOG antibody disorder preferentially causes inflammation in the optic nerve but can also cause inflammation in the spinal cord, brain and brain stem.  Loss or blurring of vision in one or both eye,Loss of color vision, Paralysis (no motor function) of a limb or limbs, Paraparesis (weakness) of a limb or limbs, Loss of sensation and Loss of bladder control, are some of the symptoms.

Paddy Kalish OD, JD and B.Arch

You Might Also Enjoy...


An aneurysm is a bulging, weakened area in the wall of a blood vessel resulting in an abnormal widening or ballooning greater than 50% of the vessel's normal diameter (width). An aneurysm may occur in any blood vessel, but is most often seen in an artery.


Nitric oxide (NO) is one of the critical components of the vasculature, regulating key signaling pathways in health. In macro-vessels, NO functions to suppress cell inflammation as well as adhesion.


Sepsis is a serious condition in which the body responds negatively to an infection. The infection fighting processes turn on the body, causing the organs to work malfunction. Sepsis may progress to septic shock.


Merkel cell carcinoma is a rare type of skin cancer that usually appears as a flesh-colored or bluish-red nodule, often on the Face, Eyelid, Head or Neck.


Sciatica refers to pain, weakness, numbness, or tingling in the leg. It is caused by injury to or by pressure on the sciatic nerve. Sciatica is a symptom of a medical problem. It is not a medical condition by itself.


HEART FAILURE is a condition in which the heart loses efficiency, leading to a chronic mismatch between the body’s need for oxygen and what it actually gets. There is chronic difficulty breathing, uncomfortable swelling in the arms or legs (or anywhere).